Research

The benefits of PEMF have been evaluated by basic research and clinical trials in many countries. PEMF is widely used as additional therapy in Europe and by professional athletes around the world but is relatively new to the US market.

More than 10,000 scientific papers have been published about the health benefits of PEMF with more than 2,000 placebos controlled; double blind studies have proven the applicability and efficacy of PEMF for human health and well-being.

Many of the initial studies have been carried out in Russia and Eastern Europe, but more and more research is now taking place in the United States and other parts of the world.

PubMed.gov is research service of the U.S. National Library of Medicine and the National Institutes of Health for the National Center for Biotechnology Information (NCBI).

None was more thorough and conclusive than the 4 year NASA study led by Dr. Thomas Goodwin, PhD, on the ability of PEMF to improve the growth and repair of tissues in mammals. This study has proved the efficacy of PEMF therapy on human cells for healing, growth and regeneration, specifically the stimulation of neural stem cells. It is the most scientifically researched and documented field of energy medicine.

PEMF is approved by the FDA and other international certifying organizations as it has been observed to help the body tissues to heal more effectively.

Application of PEMF exhibited therapeutic efficacy on bone fractures, skin ulcers, and lower back pain (Hei et al., 2016).  Recent studies have shown that PEMF is a safe and non-invasive approach for management of several neurological diseases, including Alzheimer’s disease (Arendash et al., 2010), Parkinson’s disease (Vadalà et al., 2015), multiple sclerosis (Lappin et al., 2003), and brain injury (Rasouli et al., 2012Pena-Philippides et al., 2014).


Alzheimer's Disease

International Journal of Neuroscience. 1994 Jun. Pub Med ID : 7960477  

Improvement of visual memory and visuoconstructive performance by treatment with magnetic fields. Application of electro-magnetic fields improved visual memory and visuoperceptive functions in patients with Parkinson’s disease. Since a subgroup of Parkinsonian patients, specifically those with dementia, have co-existing pathological and clinical features of Alzheimer’s Disease. In both patients treatment with Electro-Magnetic Field resulted in a dramatic improvement in visual memory and enhancement of visuoconstructive performance which was associated clinically with improvement in other cognitive functions such as short term memory, calculations, spatial orientation, judgement and reasoning as well as level of energy, social interactions and mood. The rapid improvement in cognitive functions in response to EMF suggests that some of the mental deficits of AD are reversible.

Amyotrophic Lateral Sclerosis (Lou Gehrig’s Disease)

1997 Second World Congress for Electricity and Magnetism in Biology and Medicine, 8-13 June 1997, Bologna, Italy. A. Bellosi & R. Berget

Pulsed Magnetic Fields: A Glimmer of Hope for Patients Suffering from Amyotrophic Lateral Sclerosis. A study of 3 patients with Amyotrophic Lateral Sclerosis was treated with a pulsed magnetic field 3 times a week for about 75 sessions. All 3 patients experienced beneficial effects.

Ankle Sprains Grade I And 2

: Mil Med. 1993 Feb;158 (2):101-4. PMID: 8441490                                                                                   Pulsed, high-frequency electro-magnetic energy in the treatment of grade I and grade II ankle sprains. Significant decrease in edema was noted after one therapy

Anxiety and Chronic Low Back Pain

Nursing Outlook Journal. 2017 Sep – Oct;65 (5S):S26-S33. Pub Med ID:28893387. Nayback-Beebe et all. In the U.S. military, chronic low back pain is among the most frequent complaints for medical visits, lost work time, and attrition from active duty and the deployed setting by service members. The aim of this pilot study was to determine whether adjunctive treatment with Pulsed Electro-Magnetic Frequency (PEMF) produced significant variability in chronic low back pain symptoms and secondary health-related quality of life, mental health and disability outcomes. Prospective, randomized pilot study with repeated measures at baseline, post-treatment, and 1 month follow-up for two groups: usual care (UC) vs. UC + PEMF. Adjunctive treatment with PEMF demonstrated improvements in service members’ overall physical health-related quality of life with expected, yet statistically non- significant improvements in reported pain and LBP-related disability. There were significant between group differences in anxiety symptom severity with higher symptoms reported by the UC + PEMF group.

Arthritis

: Indian Journal of Experimental Biology 01 Dec 2009, 47(12):939-948] Ganesan K  et al. Pub Med ID:20329696

Arthritis refers to more than 100 disorders of the musculoskeletal system. The existing pharmacological interventions for arthritis offer only symptomatic relief and they are not definitive and curative. Magnetic healing has been known from antiquity and it is evolved to the present times with the advent of electro-magnetism. Low frequency pulsed electromagnetic field (PEMF) can provide non-invasive, safe and easy to apply method to treat pain, inflammation and dysfunctions associated with rheumatoid arthritis (RA) and osteoarthritis (OA) and PEMF has a long term record of safety. This review focusses on the therapeutic application of PEMF in the treatment of these forms of arthritis. The analysis of various studies (animal models of arthritis, cell culture systems and clinical trials) reporting the use of PEMF for arthritis cure has conclusively shown that PEMF not only alleviates the pain in the arthritis condition but it also affords chondroprotection, exerts anti-inflammatory action and helps in bone remodeling and this could be developed as a viable alternative for arthritis therapy.

ARTHROSIS OF THE KNEE

Journal of Rheumatology, 1993:20, pp. 456-460. D.H. Trock et al

Clinical Effects of PEMF in Osteoarthritis. Twenty seven patients with primary arthrosis of the knee. After one month. These results show a definite improvement in clinical parameters (such as mobility) in the group treated with PEMF in comparison with the group treated without PEMF. An important conclusion in this study is that for more than 17 years, more than 200,000 patients have already been treated in Eastern Europe with pulsating electro-magnetic fields in clinical trials without any mentionable side effects.

ASEPTIC LOOSENING OF TOTAL HIP PROSTHESES

Budapest, Hungary, International Journal on Clinical Rheumatology, July 1996 K. Konrad et al. PEMF was used on 24 patients with a loosened hip prosthesis. Follow-up examinations were performed after six months and after one year, showing that the patients treated with PEMF had experienced pain relief and a definite improvement in hip movements.

BACK PAIN

West Indian Medical Journal. 2013 Mar; 62(3):205-9 Pub Med ID: 24564041 Evaluation of the efficacy of pulsed electro-magnetic therapy in the treatment of back pain: a randomized controlled trial in a tertiary hospital in Nigeria. The PEMF device was applied in group A four times a day for the period the patients were admitted (maximum of nine days). There was a statistically significant faster pain relief and resumption of active functions in patients treated with PEMF plus analgesic compared with the rates exhibited by patients treated with standard analgesics alone. These results suggest that PEMF therapy is beneficial in reducing pain and disability in patients with back pain and should be made part of holistic cape for back pain

Balance Ability

2014 Jan; Pub Med ID: 24527596 PEMFs can improve the balance ability of patients with post-menopausal osteoporosis

Beneficial Effects of Electro-Magnetic Fields

Journal of Cell Biochemistry, 51(4), April 1993, p 387-393. C. A. Bassett. This article claims that over a quarter million patients worldwide with chronically un-united fractures have experienced beneficial results from treatment of electro-magnetic fields. In addition, the author cites studies pointing to the treatments efficacy with respect to other conditions such as heart attack, stroke, diabetes, un-united fractures, nerve regeneration, wound healing or graft behavior.

Benign Prostate Hypertrophy (BPH)

Journal of Physical Therapy Science. 2017 Aug; 29(8):1305-1310  PMID: 28878453

The results of the current study demonstrated that the use of PEMF and exercise therapy is beneficial in the treatment of BPH. This was presented as a significant reduction in WBCs count, PSA antigen, IPSS, and post-void residual urine in addition to the significantly increased urine flow rate. Inflammation of the prostate gland might signify a powerful factor in determining prostatic swelling and improving symptoms. The highest PEMF potential was displayed in its capacity to enhance the effects of inflammation by reducing inflammatory cytokines and improving cellular metabolism. Consequently, by diminishing the inflammatory processes, PEMF may possess the ability to overcome developments related to BPH and its associated symptoms. A study in 2011 of 20 humans showed that the clinical manifestations of BPH were significantly diminished following PEMF administration, so the influence persisted for 12 months. PEMF is a broad approach employed in the treatment of various medical dysfunctions, such as musculoskeletal disorders, neurological manifestations and urological disciplines. Clinical studies have reported its convenient role in decreasing inflammation, forming new blood vessels, and relieving pain. Plenty of clinical studies have recommended that magnetic field stimulating properties can hasten organ healing. Its application on the prostate gland helps reduce post-operative problems and was observed to excite the prostate gland and promote blood flow, demonstrating a definite impact on revascularization and the circulatory consequences of the prostate. The present study demonstrated that electromagnetic field had a significant impact on the treatment of benign prostatic hyperplasia. Accordingly, electromagnetic field can be utilized alone or in combination with other physiotherapy modalities. Moreover, clinicians should have the capacity to perceive the advantages accomplished using extra treatment alternatives. Electro-magnetic field is a safe, non-invasive method and can be used for the treatment of benign prostatic hyperplasia.

BONE FRACTURE HEALING

Bioelectromagnetics. 2016 Feb 18. Pub Med ID: 26891468. Substantial evidence indicates that pulsed electro-magnetic fields (PEMF) could accelerate fracture healing and enhance bone mass, whereas the unclear mechanism by which PEMF stimulation promotes osteogenesis limits its extensive clinical application. Significantly increased proliferation-related gene expressions at the proliferation phase were observed after PEMF stimulation.

  1. PEMF resulted in significantly increased gene and protein expressions of alkaline phosphatase and osteocalcin at the differentiation phase of osteoblasts.
  2. Moreover, PEMF upregulated gene and protein expressions of collagen type

Together, our present findings highlight that PEMF stimulated osteoblastic functions

Bone Research

Clinical Orthopaedics and Related Research, 2010 Aug; 468(8): 2260–2277. Pub Med ID: 20387020. Effects of Pulsed Electro-Magnetic Fields on Human Osteoblast-Like Cells. Vincenzo S et al University of Ferrara, Italy.                                                                                            PEMFs have been used for many years. They reportedly are effective for treating non-unions, delayed unions, osteotomies, avascular necrosis of the femoral head, bone grafts and spinal fusion.  Although the therapeutic properties of PEMFs are well known, the sequence of events by which electro-magnetic stimulation can bring about its desirable effects on bone healing is not completely understood. Our research data suggest many effects of PEMFs on human osteoblast-like cells in vitro. Stimulation by PEMFs induces bone healing in patients, shortens the time of healing processes, and stimulates healing of non-unions. Given their broad effects, PEMFs might be useful in other fields such as regenerative medicine.

CANCER

Journal on Cancer Medicine. 2016 Nov; 5(11):3128-3139   Pub Med ID: 27748048

Mechanisms And Therapeutic Effectiveness Of Pulsed Electro-Magnetic Field Therapy In Oncology. Available cancer treatments are associated with numerous side effects and only a low percentage of patients achieve complete remission. Therefore, there is a strong need for new therapeutic strategies.

In this regard, pulsed electro-magnetic field (PEMF) therapy presents several potential advantages including non-invasiveness, safety, and lack of toxicity for non-cancerous cells and the possibility of being combined with other available therapies.

Indeed, PEMF stimulation has already been used in the context of various cancer types including skin, breast, prostate, hepatocellular, lung, ovarian, pancreatic, bladder, thyroid, and colon cancer in vitro and in vivo.

In oncology, the selection of correct treatment strategy, in early disease stages, is crucial to increase the probability of remission and improve survival. Multimodal treatments are often required to reduce the therapy‐induced side effects related to pharmacological as well as other approaches including surgery. 

Numerous studies support the development of new treatments in oncology to be added to the traditional protocols to increase the effectiveness of available treatments, reducing side effect profile, and the patients’ quality of life. The beginning of the 20th century saw the first therapeutic applications of additional therapies for cancer treatment; these therapies include pulsed electro-magnetic field (PEMF) therapy.

In this review, we have focused on PEMF therapy, a non-invasive technique characterized by electro-magnetic fields to the entire body or locally to target specific body tissues. Exposure to PEMFs is a therapeutic tool extensively used for the treatment of osteoarthritis, Parkinson’s disease, post-surgical pain and edema, treatment of chronic wounds, and facilitation of vasodilatation and angiogenesis producing direct stimulation to excitable cells including nerve and muscle cells.

Stimulation with sufficient intensity and duration induces a current across targeted cell membranes, activating nerve cells or muscles to propagate action potentials. Indeed, PEMF therapy can be used as an adjuvant therapy to chemotherapy and radiotherapy with the aim of reducing their dosage, mitigating any harmful secondary side effects and enhancing patient’s prognosis.

In vitro studies support anti-neoplastic and anti-angiogenic effects of PEMF therapy. Several mechanisms of PEMF therapy have been elucidated. For example, PEMFs inhibit cancer growth by disrupting the mitotic spindle in a process mediated by interference of spindle tubulin orientation and induction of dielectrophoresis.

Furthermore, PEMF therapy modulates gene expression and protein synthesis interacting with specific DNA sequences within gene promoter regions.

In addition, PEMFs inhibit angiogenesis in tumor tissues, suppressing tumor vascularization and reducing tumor growth, as shown by in vivo studies.

The specific claim, supported by the described in vivo studies, is that all treated groups showed slower tumor growth rate if compared with untreated control group, confirming that PEMF therapy can modulate the physiology and electrochemistry of cancer cells and influence cell membrane systems and mitosis.

In addition, PEMFs induce some changes in membrane transport capacity through impacting the osmotic potential, ionic valves and leading to reduction in cellular stress factors, increase in the rate of DNA transcription, and modulation of immune response.

PEMFs have also an immune-modulatory effect, as supported by in vivo evidence showing an increase in tumor necrosis factor alpha levels that induce an anti‐tumoral response, leading to the activation of a pro-apoptotic pathway induced by caspase‐8 interaction with Fas‐associated death domain, in the spleen of the murine melanoma mouse model after a 16‐day therapy.

Changes in blood pressure, skin electrical resistance, and pulse amplitude in 163 oncology patients exposed to tumor‐specific PEMF frequencies have also been reported suggesting that PEMF therapy does not only target neoplastic cells, but may also have systemic effects.

However, long‐term PEMF treatment in HCC patients is not toxic, confirming the safety of PEMF therapy that employs 100,000 times lower frequencies if compared with radiofrequency ablation that is also employed for treatment of hepatocellular carcinoma (HCC).

In conclusion, only two clinical studies have used PEMF therapy for cancer treatment. These studies show that PEMF therapy is safe and promising compared to other available cancer therapies.

In the future, PEMFs could be used not only as primary therapy but also in combination with other common anti-neoplastic therapies. Given that new portable and affordable PEMF devices are increasingly available on the market, future controlled clinical studies are expected to further determine the potential of PEMF therapy in oncology.

Bronchitis

Voen Med Zh, 3, 1989, . 35-36. V.M. Iurlov, et al. The Efficacy of the Use of Low-Frequency Electromagnetic Fields in Chronic Bronchitis. Results of this double-blind, placebo-controlled study indicated that both low-frequency electro-magnetic field treatment and treatment with pulsed electro-magnetic fields proved effective in patients suffering from chronic bronchitis when coupled with standard drug therapies. Magnetic field treatment consisted of a total of fifteen 15-20 minutes daily exposures

CARTILAGE

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA [01 Jul 2007, 15(7):829] Zorzi C et al. Pud Med ID: 17333120 Effects of pulsed electro-magnetic fields on patients’ recovery after arthroscopic surgery. Severe joint inflammation following trauma, arthro-scopic surgery or infection can damage articular cartilage, thus every effort should be made to protect cartilage from the catabolic effects of pro-inflammatory cytokines and stimulate cartilage anabolic activities. Previous pre-clinical studies have shown that pulsed electro-magnetic fields (PEMFs) can protect articular cartilage from the catabolic effects of pro-inflammatory cytokines and prevent its degeneration, finally resulting in chondroprotection. These findings provide the rational to support the study of the effect of PEMFs in humans after arthroscopic surgery. All patients were instructed to use PEMFs for 90 days, 6 hours per day. The percentage of patients who used non-steroidal anti-inflammatory drugs (NSAIDs) was 26% in the active group and 75% in the control group. At 3 years follow-up, the number of patients who completely recovered was higher in the active group compared to the control group. Treatment with I-ONE aided patient recovery after arthroscopic surgery, reduced the use of NSAIDs, and also had a positive long-term effect.

Depression

Nevrol Psikhiatr Im S S Korsakova. 1996; 96(6):28-31. Morozov GV et al. Pub Med ID: 9072890.                 The treatment of neurotic depression by using extremely high-frequency electro-magnetic radiation. Extremely high frequencies of electro-magnetic waves were used for the treatment of 53 women with asthenic, anxious and combined forms of depressions together with other methods (psycho-pharmacological treatment and psychotherapy). Recovery was observed in 50.9% of cases, considerable improvement in 41.5% and the improvement in 7.6% of cases. The highest therapeutic effect was observed in patients with asthenic neurotic depression (recovery in 66.7%).

Diabetes

Klin Med, 74(5), 1996. P 39-41. I.B. Kirillovm et al

Comprehensive Treatment of Vascular Complications of Diabetes Mellitus. In this study, 320 diabetics received impulsed magnetic field treatment while 100 diabetics (controls) received conservative therapy alone. Results showed beneficial effects with respect to vascular complications in 74 percent of the patients with PEMF achieving positive results

Diabetic Polyneuropathy

International Journal of  Diabetes in Developing Countries. 2009 Apr-Jun; 29(2): 56–61. Vinay Graak et al. Pub Med ID: 20142869. Evaluation of the efficacy of Pulsed Electro-Magnetic Field in the management of patients with diabetic polyneuropathy.

Diabetic neuropathy is a common microvascular complication of diabetes over time and one of the major causes of non-traumatic amputations. The experimental groups 1, 2 were treated with low-frequency Pulsed Electro-Magnetic Field of 600 and 800 Hz, respectively. The actions of PEMF were directed bilaterally on calf muscles of both lower limbs; each field was applied for 30 min. duration for 12 consecutive days. In summary, it can be concluded that available data provide the evidence that PEMF treatment has the potential to modulate neuropathic pain and nerve impulse. It may be due to decrease in endo-neural hypoxia, perineural edema, ischemia of peripheral nerves, and improved microcirculation that leads to positive changes after treatment sessions. The present study provides convincing data regarding the effect of PEMF on neuropathic pain and nerve impulse. Considering its benefit and safety, low-frequency PEMF can be used as an adjunct in the management of diabetic neuropathy cases. 

Duchenne-Erb-Disease

Electro-Magnetic Waves in Complex Therapy of Children with Birth Trauma. Effects of Ultra High Frequency Electric Fields on Central Hemodynamics and the Shoulder Plexus, Vopr Kurortol Fizioter Lech Fiz Kult, (4), 1992, p 35-38.

This study examined the effects of Electro-Magnetic Fields in the treatment of 5 year old children suffering from Duchenne-Erb-Disease. Children were exposed to either UHF or DMW therapy for 8-12 minutes per day on alternating days over a period of approximately 10 days. Following the electro-magnetic fields course, children received mud applications on the collar area and injured extremity. Results showed that treatment decreased contractures in shoulder and elbow joint, increased mobility and muscle strength and improved general function of the arm.

Erectile Dysfunction

Vopr Kurortol Fizioter Lech Fiz Kult. 2007 Puub Med ID: 17882824                                       Combined treatment with local negative pressure and pulsating magnetic field conducted in 116 patients with erectile dysfunction aged 20-60 years produced optimal treatment results. Recovery and improvement of the erectile function were achieved in 85.7% patients given local vacuum-magneto-therapy

EYE REPAIR AND REDUCTION OF INFLAMMATION IN THE EYE

Antibiotiki. 1982 Verzin AA   Action of gentamycin against a background of magneto-therapy of the anterior chamber in a traumatic infected erosion of the cornea. PEMF as additional therapy on the eye can be taken as demonstrating repair and reduction of inflammation in the eye in general as well as specifically in glaucoma. Fifteen patients with surface infections of the cornea due to a foreign body in one eye were treated with PEMF for 9 minutes and the topical antibiotic gentamycin before and after removal of the foreign bodies. This treatment promoted suppression of the inflammatory reaction of the eye and accelerated corneal tissue regeneration. This study establishes that PEMFs can accelerate healing of not only inflammation but also eye tissue damage.

EYES - Alkaline-Burned Corneas

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7881-7888

Short-term effects of extremely low frequency pulsed electro-magnetic field on corneas with alkaline burns in rabbits. Short-term ELF-PEMF therapy is a safe, non-invasive, and markedly effective method in healing alkaline-burned corneas and its therapeutic results are comparable with those of Medical Treatment

EYES - Degenerative Diseases Of The Retina

1994. J. Jerabek, “Pulsed Magneto-therapy in Czechoslovakia–A Review,” Rev Environ Health, 10(2), April-June 1994, 127-134. This article reviews the use of magneto-therapy in Czechoslovakia. Noting that this modality has been used for more than a decade, the author states that magneto-therapy has been shown to be effective in treating rheumatic diseases, sinusitis, enuresis and ischemic disorders of the lower extremities. Positive findings have also been shown with respect to multiple sclerosis and degenerative diseases of the retina.

EYES - GLAUCOMA

Oftalmol Zh. 1990;(3):154-7. Tsisel’skiĭ IuV et al. PubMed ID: 2255478. The effect of a pulsed electro-magnetic field on the hemodynamics of eyes with glaucoma. The influence of pulse electro-magnetic field (PEMF) on hemodynamics of the eye in open-angle glaucoma has been studied at the Filatov Institute. Observations over 150 patients (283 eyes) with latent, initial and advanced glaucoma have shown a positive influence of PEMF on hemodynamics of a glaucomatous eye.

EYES - VARIETY OF EYE AND BRAIN VASCULAR DISORDERS

Magnetic Field Application for the Treatment of Vascular Diseases of the Brain and Eyes. This study examined the effects of magneto-therapy on patients suffering from a variety of eye and brain vascular disorders. Treatment with most patients receiving a course of 15-20 daily exposures. Results showed overall general improvements in 95 percent of patients with eye diseases. N. Gilinskaya & L.V. Zobina, “,” in Y.A. Kholodov & N.N. Lebedeva (eds.), Problems of Electromagnetic Neurobiology, Moscow, Nauka,1988, p. 94-98

FALLING

: International Journal of Neuroscience. 1997 Nov; 92(1-2):95-102. PMID:9522259

Multiple sclerosis (MS) is associated with an increased risk of falling resulting from visual disturbances, difficulties with gait and balance, apraxia of gait and peripheral neuropathy. This report concerns a 36 old man with remitting-progressive MS who experienced marked increase in spasticity in the legs and trunk and worsening of his gait and balance, occasionally resulting in falling, when talking while walking. His gait and balance improved dramatically after he had pulsed electro-magnetic fields (PEMFs) therapy. Simultaneously, there was improvement in dual-task performance to the extent that talking while walking did not adversely affect his ambulation. In addition, neuro-psychological testing revealed an almost 5-fold increase in word output on the Word-Fluency Test, which is sensitive to frontal lobe dysfunction. It is suggested that facilitation of dual-task performance during ambulation contributes to the overall improvement of gait and balance observed in MS patients receiving treatment with PEMF.

FATIGUE

International Journal of Neuroscience. 1996 Feb;84(1-4):177-86. Sandyk R PMID: 8707480 The present report concerns 3 MS patients who experienced continuous and debilitating fatigue throughout the course of the day over several years. Treatments with electro-magnetic fields (EMF), improves fatigue associated with multiple sclerosis. 

Fibromyalgia

Clinical Journal of Pain. 2009 Oct;25 (8):722-8. Sutbeyaz et all. Pub Med ID:19920724. Fifty-six women with FM, aged 18 to 60 years, were randomly assigned to either PEMF or sham therapy for 30 minutes per session, twice a day for 3 weeks. Treatment outcomes were assessed after treatment (at 4 weeks) and follow-up (at 12 weeks). Low-frequency PEMF therapy might improve function, pain, fatigue, and global status in FM patients.

Fracture

Non-United Fractures, Fusion Failures and Pseudo-Arthrosis: Orthopedic Review. 1986 Dec;15 (12):781-95. Pub Med ID: 3453923. A conversation with Andrew Bassett, MD. Pulsed electro-magnetic fields (PEMF), a non-invasive therapeutic modality for fracture non-union. Dr. Basset researched on use of PEMF for the past 30 years at Columbia University‘s Orthopedic Research Lab. Dr. Basset noted that about 10,000 of the 12,000 plus orthopedic surgeons in the U.S. have used PEMF on at least one patient. Many such surgeons have incorporated the PEMF therapy on a more regular basis. He estimated that at least 65,000 patients nationwide suffering from non-united fractures, fusion failures or pseudo-arthrosis had received the treatment with a probable success rate of 80%-90%.

HAIR LOSS

International Journal of Dermatology, 29(6), 1990, p 446-50. W.S. Maddin et al.

This study investigated men with alopecia to determine the effect of PEMF. After 36 weeks of treatment, it was found that the hair loss was stopped and new hair growth was promoted.

Headaches

Hungarian Symposium on Magnetotherapy, 2nd Symposium, May 16-17, 1987, Szekesfehervar, Hungary, p. 163-166. A. Prusinski, et al. This study examined the effects of pulsed electromagnetic fields, 20 minutes per day for 15 days in the treatment of patients suffering from chronic headaches. Results indicated the treatment to be most effective in patients suffering from tension headaches, with 88 percent of such patients reporting positive results. Beneficial results were also experienced patients suffering from migraines (60 percent), cervical migraines (68 percent), and psychogenic headaches (60 percent).

HEART - Atherosclerotic Encephalopathy

Vopr Kurortol Fizioter Lech Fiz Kult. 3, 1987, 36-39. S. Gabrielian et al. This study examined the effects of low frequency magnetic fields in patients suffering from atherosclerotic encephalopathy. Treatment involved 10-15 minutes daily exposures over a total of 10-15 applications. Results showed clinical improvements with respect to chest pain, vertigo, headache and other symptoms.

HEART ATTACK

American Journal of Translational Research, 2014 May 15;6(3):281-90 Pub Med ID:  24936220                                                                                                   Coronary artery disease is a leading cause of morbidity and mortality in modern society. Massive loss of cardiac muscle after several ischemic episodes leads to compromised cardiac function, remodeling and low quality life of patients. A growing body of evidence in experimental models of cardiac injury suggests that early re-establishment of blood perfusion to the injured myocardium would restrict infarct expansion, prevent cardiac remodeling and maintain cardiac function.

Pulsed electro-magnetic field improves cardiac function in response to myocardial infarction. Extracorporeal pulsed electro-magnetic field (PEMF) has shown the ability to improve regeneration in various ischemic episodes. In conclusion, our findings indicate that extracorporeal PEMF treatment increases cardiac systolic function through inhibiting cardiac apoptosis and stimulating neovascularization.

HEPATITIS

Pediatriia, 10, 1991, p. 54-57   V.V. Krasnov & A.I. Shilenok

Magneto-Therapy of Hepatitis A and B in Children. This study examined the effects of magneto therapy in children suffering from various forms of viral hepatitis. Magneto therapy consisted of alternating magnetic fields applied to the liver area daily over a total of 10-15 days. Results indicated magneto therapy led to more rapid and trouble free recovery.

HIGH & LOW BLOOD PRESSURE

Biofizika, 41(4), 1996, P 944-948 L. Orlov et al. This study examined the effects of magneto-therapy in patients suffering from neuro-circulatory hypotension (low blood pressure) or hypertension (low blood pressure). Treatment consisted of a running pulsed magnetic field administered for 20 minutes per day over a course of 10 days. Hypertension patients showed a marked improvement with respect to symptoms including headache, chest pain, extremity numbness, abnormal systolic and diastolic blood pressure and work capacity.

INSOMNIA

Adv Ther. 2001 Jul-Aug; 18(4):174-80

Impulse magnetic-field therapy for insomnia. This 4-week double-blind, placebo-controlled study assessed the efficacy of impulse magnetic-field therapy for insomnia. Fifty patients were assigned to active treatment. Seventy percent of the patients given active treatment experienced substantial or even complete relief of their complaints

KIDNEY PROBLEMS

Second World Congress for Electricity and Magnetism in Biology and Medicine, 8-13 June 1997, Bologna, Italy. V.A. Kiyatkin Pulsed Magnetic Field in Therapy of Patients with Secondary Chronic Pyelonephritis This review article notes that placebo-controlled studies have shown positive results concerning the use of Pulsed Electro-Magnetic Field therapy (PEMF) in the treatment of secondary chronic pyelonephritis

LARYNX DISEASES

D.I. Tarasov, et al., “,” Vestn Otorinolaringol, (6), November-December 1995, 11-15. Effectiveness of Local Magnetic Field of the Acoustic Frequency in the Treatment of Patients with Acute Inflammatory Diseases of the Larynx. Results of this study found that alternative magnetic field of sound frequency proved to be an effective treatment in patients suffering from acute inflammatory diseases of the larynx

LUNG DISEASE

Probl Tuberk, 3, 1988, p. 53-56. L.V. Iashchenko

This study examined the effects of low-frequency magnetic fields (PEMF) coupled with conventional therapies in rats suffering from inflammatory lung disease. Results showed that rats receiving the magnetic fields experienced significant reductions in lung abscesses and associated symptoms, and similar beneficial effects were seen among a group of 165 human patients receiving comparable treatment.

LUPUS ERYTHEMATOSUS

Ter Arkh, 67(10), 1995, p. 84-87. I.V. Khamaganova, et al

This review article examined the data concerning pulsed magnetic fields (PEMF) in the treatment of lupus erythematosus. Studies indicate that the treatment can be beneficial due to its anti-inflammatory and analgesic effects, its positive action on microcirculation, and immunological reactivity

Multiple Sclerosis

International Journal of Neuroscience, V 90, 1997, Issue 3-4. R Sandyk. It is estimated that 10–20% of patients with multiple sclerosis (MS) have a chronic progressive (CP) course characterized by an insidious onset of neurological deficits followed by steady progression of disability in the absence of symptomatic remission. To date no therapeutic modality has proven effective in reversing the clinical course of CP MS although there are indications that prolonged treatment with electro-magnetic fields (EMFs) alters the clinical course of patients with CP MS. A 40 year-old woman presented in December of 1992 with CP MS with symptoms of spastic paraplegia, loss of trunk control, marked weakness of the upper limbs with loss of fine and gross motor hand functions, severe fatigue, cognitive deficits, mental depression, and autonomic dysfunction with neurogenic bladder and bowel incontinence. Her symptoms began at the age of 18 with weakness of the right leg and fatigue with long distance walking and over the ensuing years she experienced steady deterioration of functions. In 1985 she became wheelchair dependent and it was anticipated that within 1–2 years she would become functionally quadriplegic. In December of 1992 she began experimental treatment with EMFs. While receiving regularly weekly transcortical treatments with AC pulsed EMFs, she experienced during the first year improvement in mental functions, return of strength in the upper extremities, and recovery of trunk control. During the second year she experienced the return of more hip functions and recovery of motor functions began in her legs. For the first time in years she can now initiate dorsiflexion of her ankles and actively extend her knees voluntarily. Over the past year she started to show signs of redevelopment of reciprocal gait. Presently, with enough function restored in her legs, she is learning to walk with a walker and is able to stand un-assisted and maintain her balance for a few minutes. She also regained about 80% of functions in the upper limbs and hands. Most remarkably, there was no further progression of the disease during the 4 years course of magnetic therapy. This patient’s clinical recovery cannot be explained on the basis of a spontaneous remission. It is suggested that pulsed applications of EMFs affect the neurobiological and immunological mechanisms underlying the pathogenesis of CP MS.

NERVOUS SYSTEM

Frontiers in Neuroscience, 2017 Feb 6; 11:42 Li X et al.

A pulsed electro-magnetic field (PEMF) exerts therapeutic effects on the nervous system, but its specific mechanism associated with excitotoxicity is still unknown.

The combination of low frequency magnetic fields and induction of micro-currents constitutes a basic mechanism underlying the biological effects of PEMF (Yamaguchi-Sekino et al., 2011). The benefits of PEMF have been evaluated by basic research and clinical trials in many countries. Application of PEMF exhibited therapeutic efficacy on bone fractures, skin ulcers, and lower back pain (Hei et al., 2016).

Recent studies have shown that PEMF is a safe and non-invasive approach for management of several neurological diseases, including Alzheimer’s disease (Arendash et al., 2010), Parkinson’s disease (Vadalà et al., 2015), multiple sclerosis (Lappin et al., 2003), and brain injury (Rasouli et al., 2012; Pena-Philippides et al., 2014).

Previous studies have shown that PEMF could modulate inflammation after traumatic brain injury by inhibiting production of pro-inflammatory factor IL-1β (Rasouli et al., 2012). Similar results were obtained from PEMF exposure after brain ischemia, which indicated that PEMF influences neuro-inflammation via elevation of anti-inflammatory IL-10 and reduction of pro-apoptotic tumor necrosis factor (Pena-Philippides et al., 2014).

In addition to inflammation, excitotoxicity induced by over production of excitatory transmitters, such as glutamate, participates in various pathophysiological processes of neurological diseases, especially acute brain injury (stroke and brain trauma) (Chamorro et al., 2016; Hinzman et al., 2016).

In an attempt to reduce glutamate-induced excitotoxicity by PEMF at the cellular level, we showed that PEMF exposure could efficiently increase cell viability and inhibit LDH release in HT22 cells. This supports the hypothesis that glutamate-induced excitotoxicity is another target for the neuro-protective effects of PEMF against acute brain injury.

In addition, we tried three different protocols for applying PEMF. Although a single PEMF exposure before (protocol 1) or after (protocol 2) glutamate treatment improved cell viability, a double PEMF exposure (protocol 3) showed better neuro-protective effects compared with a single PEMF exposure. This result suggests that multiple PEMF exposures with specific intervals might be a potential method for reduction of neuronal injury.

Osteoarthritis-Bilateral Knee

Clinical Interventions in Aging, 2013;8:1289-93. PMID: 24106421.

Pulsed electro-magnetic field (PEMF) therapy has shown promising therapeutic effectiveness on bone and cartilage related pathologies, being also safe for management of knee osteoarthritis. Twenty eight patients, aged between 60 and 83 affected by bilateral knee osteoarthritis, were enrolled in this study. They received PEMF therapy on the right leg for a total of three 30-minute sessions per week for a period of 6 weeks. The present study shows that PEMF therapy improves pain, stiffness and physical function in elderly patients affected by knee osteoarthritis

Osteonecrosis-Steroid-Induced

Bio Med Central Musculoskeletal Disorders. 2011 Sep 29; 12:215. Pub Med ID: 21958301.            

Pulsed electromagnetic fields (PEMF) stimulation has been used successfully to treat non-union fractures and femoral head osteonecrosis. PEMF stimulation can prevent steroid-induced osteonecrosis in rats. Because PEMF stimulation is effective, safe and non-invasive, it provides a useful prophylaxis for steroid-induced osteonecrosis

Osteoporosis

The Journal of Bone and Mineral Research, 1990 May; 5(5):437-42. Tabrah F et al. Pub Med ID: 2195843. To determine the effect of a pulsating electro-magnetic field (PEMF) on bone density of the radii of osteoporosis-prone women, the non-dominant forearms of 20 subjects were exposed to PEMF 10 h daily for a period of 12 weeks. The data suggest that properly applied PEMFs, if scaled for whole-body use, may have clinical application in the prevention and treatment of osteoporosis.  

Osteotomy

Clinical Orthopedics.1988 Dec; (237):256-63 Traina et al,  Low-frequency pulsing electro-magnetic fields (PEMF) are being used in non-union healing at several centers around the world. Thirty two patients with femoral intertrochanteric osteotomy for hip degenerative arthritis are treated with PEMF. PEMF stimulation favored osteotomy healing. Department of Orthopedics and Traumatology, Montecchio Hospital, Reggio Emilia, Italy. PMID: 3191636.

Other Diseases

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem IpsuCas Lek Cesk, 132(19),Oct 1993, . 590-594. L. Navratil, et al                                                                                                               Possible Therapeutic Applications of Pulsed Magnetic Fields. General results of this study indicated that the optimal frequency of pulsed magnetic fields ranges between 10.0 and 25.0 Hz in the treatment of chronic inflammatory conditions of the locomotor apparatus, ischemia of the blood vessels of the lower extremities, dyspeptic syndrome, lactation mastitis, and other diseases. Treatment proved best when the therapeutic cycle was repeated after a 2-3 month periodm has been the industrys standard dummy text ever since the 1500s.

Peripheral Neuropathy

Neuro- Rehabilitation & Neural Repair Medical Journal, 2004 Mar; 18 (1):42-6. Weintraub et all. Pub Med ID:15035963. Pulsed Magnetic Field therapy in refractory neuropathic pain secondary to peripheral neuropathy: electro-diagnostic parameters–pilot study. These pilot data demonstrate that directing PEMF to refractory feet can provide unexpected short term analgesic effects in more than 50% of individuals.

PLASTIC SURGERY

Aesthet Surg J. 2009 Mar-Apr. Pub Med ID: 19371845                  Evidence-based use of pulsed electromagnetic field therapy in clinical plastic surgery. Our objective was to review the major scientific breakthroughs and current understanding of the mechanism of action of PEMF therapy, providing clinicians with a sound basis for optimal use. A holistic exposition on the clinical use of PEMF in plastic surgery was performed. PEMF therapy has been used successfully in the management of post-surgical pain and edema, the treatment of chronic wounds, and in facilitating vasodilatation and angiogenesis. Using scientific support, the authors present the currently accepted mechanism of action of PEMF therapy. This review shows that plastic surgeons have at hand a powerful tool with no known side effects for the adjunctive, non-invasive, non-pharmacologic management of post-operative pain and edema. Given the recent rapid advances in development of portable and economical PEMF devices, what has been of most significance to the plastic surgeon is the laboratory and clinical confirmation of decreased pain and swelling following injury or surgery

Psoriasis

Ospedale die Bambini [Children’s Hospital]. V. Buzzi, Milan. Minerva Med. R. Castelpietra et al

The therapeutic success of PEMF in psoriasis was investigated on 110 patients. The best results were achieved in the area of the head and hair (100%) good results, in the typical locations/joints: 73.7% in men and 75% in women. The best results were achieved by people in the 2nd, 5th and 6th decades of life. The prospects for success were better, the longer the disease had been in existence in a given patient.

Psoriatic Arthritis

Vopr Kurortol Fizioter Lech Fiz Kult, (6), 1995.                     In this review article on the treatment of patients with psoriatic arthritis with magnetic fields, the authors state that an alternating low-frequency magnetic field improves the clinical state of afflicted joints. Such treatments are normally carried out for 30 minutes per day over a period of 15 to 20 days. V.D. Grigor’eva, et al. Pub Med ID:  8713314 

Rheumatoid Arthritis (RA)

Rheumatoid Arthritis (RA) Awareness Week, organized by the National Rheumatoid Arthritis Society (NRAS) in UK. NRAS, occurs on 19–25th June 2017 and is an important week to raise awareness and challenge misconceptions and attitudes about RA. Pulsed Electro Magnetic Fields (PEMF) technology offers RA sufferers a drug-free, pain-relief therapy that can also help improve their mobility and help them reduce their pain medication

Rotator Cuff Tears

Orthopedic Research Society, 2017 Apr;35 (4):902-909. Pub Med ID: 27282093.

Rotator cuff tears are common muscular-skeletal injuries often requiring surgical intervention with high failure rates. Currently, pulsed electro-magnetic fields (PEMF) are used for treatment of long-bone fracture and lumbar and cervical spine fusion surgery. Clinical studies examining the effects of PEMF on soft tissue healing show promising results. Therefore, we investigated the role of PEMF on rotator cuff healing using a rat rotator cuff repair model. At 16 weeks the PEMF group had improved bone quality. Therefore, results indicate that PEMF improves early tendon healing and does not alter joint function in a rat rotator cuff repair model.

Regeneration Of Osseous, Cartilaginous And Muscular Tissues In Children.

A Contact Free Biologically Adequate Electro-Magnetic Stimulation Of Repair; Regeneration Of Osseous, Cartilaginous And Muscular Tissues In Children. Vestn Ross Akad Med Nauk, (3), 1994. P 38-42. This article reports on the efficacy of a Russian electro-magnetic stimulation device. Data from 508 patients suffering from various ailments like stubborn fractures, post-traumatic contractures, crush syndrome and Perthes’ disease treated with electro-magnetic stimulation showed 75%-100% effective.

Review

J. Jerabek, “Pulsed Magnetotherapy in Czechoslovakia–A Review,” Rev Environ. Health, 10(2), April-June 1994, 127-134. This article reviews the use of magneto-therapy in Czechoslovakia. Noting that this modality has been used for more than a decade, the author states that magneto-therapy has been shown to be effective in treating rheumatic diseases, sinusitis, enuresis, and ischemic disorders of the lower extremities. Positive findings have also been shown with respect to multiple sclerosis and degenerative diseases of the retina.

Variety Of Purposes

Bioelectromagnetics Society, 4th Annual Meeting, 1982, LA, CA. R.A. Drolet, “Rhumart Therapy. A Non-invasive Cell Regeneration Ion and Anti-Inflammatory Therapy Using LF-EM Fields. This review article notes that low-frequency electro-magnetic therapy has been used for a variety of purposes. Those specifically identified by the author include cell growth promotion, pain reduction, improved blood circulation, bone repair, increased wound healing, sedative effects, enhanced sleep, and arthritic relief.

Various Diseases

Fizicheskaia Meditzina, 4(1-2), 1994, p. 87 V.I. Kovalchuk, et al.

Use of Extremely-Low-Frequency Magnetic Fields in Clinical Practice This study examined the effects of extremely low frequency magnetic fields (PEMF) in the treatment of a group of 650 patients suffering from a host of various diseases. Treatment consisted 15-25 minute daily exposures 5 days per week over a total of 20-25 days. Most patients experienced improvements after 2-3 exposures. Marked improvements were seen with respect to analgesic, anti-inflammatory, anti-tumor, and immune-enhancing effects

VERTEBRAL SYNDROME, GONARTHRITIS AND COXARTHRITIS

Bratisl Lek Listy. 1999 Dec;100(12):678-81 Korpas Et Al, Ist Dpt of Internal Medicine, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. Personal experience in the use of magneto-therapy in diseases of the musculo-skeletal system. The aim of this study was therefore the treatment of 576 patients who suffered from vertebral syndrome, gonarthritis and coxarthritis. In the time of pulsatile electro-magneto-therapy the patients were without pharmacotherapy or other physiotherapy. The application of pulsatile electro-magnetic field is a very effective therapy of vertebral syndrome, gonarthritis and coxarthritis. Owing to regression of edema and pain relief the motility of patients improved.

Wide Range Of Disorders

International Journal of Rehabilitation Research,16 (4),1993, p.323-327. Begue-Simon & R.A. Drolet, This research examined the effects of low-frequency pulsed electro-magnetic fields on patients suffering from a wide range of disorders, including musculoskeletal disorders, neurological disorders, circulatory diseases, traumatic disorders, gastroenterological problems, and stress-related morbidity. Results, based on the patients’ own subjective ratings, indicated the treatment to be beneficial across most conditions, with the strongest effects seen in those suffering from musculoskeletal and traumatic disorders.

Wide Variety Of Conditions

Vopr Kurortol Fizioter Lech Fiz Kult, (2), 1979. V.M. Bogoliubov & L.A. Skurikhina.

This review article cites studies pointing to the efficacy of low-frequency magnetic fields in the treatment of a wide variety of conditions, arterial aneurysms, burns, arthritis, fractures, premenstrual syndrome, phantom pain, tuberculosis, ischemic heart disease, hypertension, bronchial asthma, and ulcerated varicose veins, among others.

Wounds

Wien Med Wochenschr. 2007 Jan;157(1-2):34-6 Pub Med ID: 17471830                                                                                                         Pulsed Electro-Magnetic Fields (PEMF)–results in evidence based medicine. Therapy with electro-magnetic fields has a very old tradition in medicine. The indications are widespread, whereas little is known about the effects. Controlled randomized studies with positive results for pulsed electro-magnetic fields (PEMF) are available for osteotomies, the healing of skin wounds, and osteoarthritis

Wounds - Diabetic

Diabetic Wounds Healing: https://doi.org/10.1371/journal.pone.0191074. Choi et al. Jan 11, 2018 Effects of pulsed electromagnetic field (PEMF) on the tensile biomechanical properties of diabetic wounds at different phases of healing.

People with diabetes have difficulty in wound healing and medical interventions are required to enhance healing. Without proper glycemic control, managements of complications and suitable footwear, diabetic foot ulcers will develop and this may lead to chronic ulcers and even amputations which severely decrease the patients’ quality of life.

Pulsed electromagnetic field (PEMF) has been used clinically as an intervention to enhance healing of chronic ulcers. Previous studies have shown that PEMF accelerated wound closure, reduced wound pain, enhanced healthy granulation and promoted circulation. A systematic review concluded that PEMF could significantly accelerate the healing of chronic ulcers (decubitus, venous and plantar) in patients.

On the other hand, animal studies also provide evidence for the use of PEMF in enhancing wound healing. Generally in non-diabetic models, PEMF reduced wound size, resolved inflammation, accelerated re-epithelialization, promoted vascular growth, improved fibroblast maturation, enhanced collagen deposition and increased the tensile strength of cutaneous wounds.

For diabetic models, there were impairments in wound closure, vascular growth and tensile strength of wound as compared to non-diabetic animals. PEMF has been shown to rescue the impairments, and accelerate wound closure], promote vascular growth, improve blood circulation, increase myofibroblast population, enhance collagen deposition and increase tensile strength in the diabetic wound models.

Biomechanical properties of wounds are contributed by the underlying structure. For example, tensile biomechanical properties are mainly contributed by the amount of collagen, fibril alignment and fiber orientation. The assessment of biomechanical properties of wounds can reveal the functional outcome of the wound tissue. Recently, our research team has demonstrated that PEMF promotes collagen deposition in diabetic wounds.

Ottani et al. showed that PEMF produced overall improvements on wound closure, neo-vascular growth and collagen deposition. The present study successfully demonstrates that PEMF of the two intensities altered the tensile biomechanical properties of the diabetic wounds differently at various phases of healing.

This study was the first study that examined the effects of PEMF on various tensile biomechanical properties of diabetic wounds over a period of time. It had lasted for 3 weeks so as to cover the inflammatory, proliferative and part of the remodeling phases of wound healing. In terms of wound closure, our findings were in line with those reported by other authors, suggesting that PEMF could enhance wound closure.

The present findings illustrated that PEMF delivered at lower intensity might be more effective in enhancing wound closure, at least in the early phase of diabetic wound healing. Both Callaghan et al. and Goudarzi et al. found that PEMF could reduce the time for complete closure in diabetic wounds.

 

The present study speculated that 10-mT PEMF can probably augment proliferation and collagen deposition in the early phase of healing that is associated with an increased energy absorption capacity and wound thickness, whereas 2-mT PEMF may enhance proliferation in the later phase.

 

Our previous studies showed that PEMF can increase collagen deposition, possibly due to increased proliferation or differentiation of myofibroblast, Fibroblast growth factor-2 (FGF-2) is one of the growth factors playing critical roles in wound healing.

 

Callaghan et al. [14] found that PEMF increased level of FGF-2 in a mouse diabetic wound model. The increased FGF-2 level could contribute to enhanced cell proliferation and collagen deposition. In line with the collagen deposition and proliferation enhancing effect of PEMF-mediated FGF-2 increase, Tepper et al. [24] reported that PEMF increased endothelial release of FGF-2 in vitro, and the PEMF-treated endothelial FGF-2 enriched medium promoted in vitro fibroblast proliferation, which is critical for collagen deposition in wound healing. 

PEMF has been demonstrated to increase proliferation and collagen deposition.

Another important growth factor in wound healing is transforming growth factor beta (TGFβ). PEMF enhances the activity of osteoblast and inhibit that of osteoclast.

 

In conclusion, a 3-week exposure to PEMF of 10 mT and 25 Hz significantly increased energy absorption capacity and appeared to increase maximum load in the early proliferative phase, but decreased Young’s modulus in the remodeling phase of diabetic wounds. At the examined time points, the current PEMF protocols (both the 2-mT and 10-mT) thickened the wounds but reduced the maximum stress of diabetic wounds. PEMF may be effective to improve the tensile biomechanical strength of diabetic wounds during wound healing.